Figure 7.

GSK3β and MEK specific inhibitors protect against H₂O₂-induced cell death. SH-SY5Y cells were treated with SB415286, U0126 or SB415286 + U0126 (SB+U) at the indicated concentrations. After 2 h, cells were exposed to 150 μM H₂O₂. Cell viability was analyzed by MTT assay at 24 h after H₂O₂ exposure. Data were presented as the mean ± SEM of three separate experiments; ^## p < 0.01 vs. the control group, *p < 0.05 and **p < 0.01 vs. H₂O₂-treated group, ^& p < 0.05 vs. H₂O₂ + 20 μM SB415286 group (ANOVA and Tukey’s test).