Table 1.

High anion gap metabolic acidosis and mixed acid–base disorders.

ΔAG = ΔHCO3−	Pure anion gap acidosis
ΔAG < ΔHCO3−	Anion gap acidosis + normal gap metabolic acidosis (renal tubular acidosis)
ΔAG > ΔHCO3−	Anion gap acidosis + metabolic alkalosis (primary aldosteronism, hypercortisolism, contraction alkalosis and diuretic use)
ΔAG >> ΔHCO3−	Anion gap acidosis + metabolic alkalosis + primary respiratory alkalosis (hypoxia)

Δ, change; AG, anion gap; HCO₃⁻, bicarbonate.