Table 4. Genotypic drug susceptibility testing results, cluster of multidrug-resistant tuberculosis, Austria, Romania and Germany, 2010 to 2014 (n = 13).
ID | H | R | R | Z | E | E | E | Eth/Pt | Eth/Pt | Ami | S | SM | PAS | FQ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rv1908c | Rv0667 | Rv0667 | Rv2043c | Rv3795 | Rv3795 | Rv3795 | Rv3854c | Rv3854c | MTB000019 | Rv3919c | Rv0682 | Rv2764c | Rv0007 | |
katG [26] | rpoB [8,25] | rpoB [8,25] | pncA [27] | embB [8,28] | embB [8,28] | embB [8,28] | ethA [29] | ethA [29] | Rrs [8] | gidB [25] | rpsL [25] | thyA [30] | gyrA [8] | |
I | S315T a | WT | S450L a | A146V a | WT | WT | D1024N b | WT | Ins 802 ag b | WT | Q125_ b | WT | R222Cb | A288Db |
II | S315T a | WT | S450L a | A146V a | M306I a | WT | WT | Ins 1391 a b | WT | WT | Q125_ b | WT | WT | WT |
III | S315T a | WT | S450L a | A146V a | WT | G406Sa | D1024N b | WT | WT | WT | Q125_ b | WT | WT | WT |
IV | S315T a | WT | S450L a | A146V a | M306I a | WT | WT | Ins 1391 a b | WT | WT | Q125_ b | WT | WT | WT |
V | S315T a | WT | S450L a | A146V a | M306I a | WT | WT | Ins 1391 a b | WT | WT | Q125_ b | WT | WT | WT |
VI | S315T a | WT | S450L a | A146V a | WT | G406S a | D1024N b | WT | WT | 1401 A -> G a | Q125_ b | WT | WT | WT |
VII | S315T a | WT | S450L a | A146V a | WT | G406S a | D1024N b | WT | WT | WT | Q125_ b | WT | WT | WT |
VIII | S315T a | WT | WT | A146V a | WT | WT | WT | WT | WT | WT | Q125_ b | WT | WT | WT |
IX | S315T a | WT | S450L a | A146V a | M306I a | WT | D1024N b | WT | WT | WT | Q125_ b | WT | WT | WT |
X | S315T a | WT | S450L a | A146V a | M306I a | WT | WT | Ins 1391 a b | WT | 1401 A- > G a | Q125_ b | WT | WT | WT |
XI | S315T a | WT | S450L a | A146V a | WT | G406S a | D1024N b | WT | WT | WT | Q125_ b | WT | WT | WT |
XII | S315T a | T400A a | S450L a | WT | WT | WT | WT | WT | WT | WT | WT | K43R1 | WT | WT |
XIII | S315T a | T400A a | S450L a | WT | WT | WT | WT | WT | WT | WT | WT | K43R1 | WT | WT |
Ami: aminoglycoside; E: ethambutol; Eth: ethionamide; FQ: fluroquinolones; ID: unique patient identifier; H: isoniazid; PAS: para-aminosalicylic acid; Pt: protionamide; R: rifampicin; S: streptomycin; Z: pyrazinamide; WT: wild type.
a resistance mediating mutation.
b resistance associated variant.