Table 1.

Different loss-of function strategies for the dissection of a lncRNA locus. Affected elements of the gene by a specific perturbation method are indicated by (+)

perturbation	DNA	transcription	RNA	protein
whole gene ablation	+	+	+	+
reporter gene insertion	+	−	+	+
CRISPRi	(+)	+	+	+
RNAi	−	−	+	+
LNA	−	−	+	+