TABLE 1.

Summary of results for PAO1 treated with the pel repressor small molecules

Parameter	Result fora:
	Antibiofilmb/antivirulence				Antibiofilmb			Pel/Psl repressors
	I7	I9	I10	I11	I2	I12	I13	I1	I4	I5	I6	I8
pelB expression	+++	++	+++	++	++	+++	++	+++	+++	+++	++	+++
pslA expression	+++	−	−	++	++	−	+++	+++	++	+++	+++	+++
CR assay (EPS)	++	+	+++	+	+++	++	++	−	−	−	+	−
CV assay (biofilm)	++	++	++	++	++	++	−	−	−	−	−	+
Flow biofilm assay (depth)	++	−	++	++	+	++	+++	NDc	ND	−	ND	ND
Nematode antivirulence	+	+	+	+	−	−	−	−	−	−	−	−
Anaerobic biofilm	−	++	−	ND	−	++	−	++	−	+	++	−

^aStatistically significant repression effects were scored as mild (+ [>15%]), moderate (++ [>30%]), strong (+++ [>50%]), or no effect (−).

^bCompounds were grouped as antibiofilm molecules if they reduced at least 2 out of 3 aerobic biofilm phenotypes (CR, CV, or flow biofilm assays).

^cND, not determined.