TABLE 1.
Antimicrobial activity of omadacycline against the main organisms and organism groups of isolates studied
| Organism/organism group (no. of isolates) | No. (cumulative %) of isolates at MIC (μg/ml) of: |
MIC50 | MIC90 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | |||
| Staphylococcus aureus (18,577) | 4 (<0.1) | 100 (0.6) | 1754 (10.0) | 11833 (73.7) | 3821 (94.3) | 707 (98.1) | 235 (99.3) | 106 (99.9) | 17 (100.0) | 0.12 | 0.25 | ||||
| MSSA (10,836) | 3 (<0.1) | 71 (0.7) | 1106 (10.9) | 7099 (76.4) | 2170 (96.4) | 356 (99.7) | 24 (99.9) | 7 (100.0) | 0.12 | 0.25 | |||||
| MRSA (7,741) | 1 (<0.1) | 29 (0.4) | 648 (8.8) | 4734 (69.9) | 1651 (91.2) | 351 (95.8) | 211 (98.5) | 99 (99.8) | 17 (100.0) | 0.12 | 0.25 | ||||
| CoNS (2,992) | 17 (0.6) | 121 (4.6) | 751 (29.7) | 589 (49.4) | 385 (62.3) | 771 (88.0) | 339 (99.4) | 19 (100.0) | 0.25 | 1 | |||||
| MS-CoNS (837) | 9 (1.1) | 65 (8.8) | 291 (43.6) | 206 (68.2) | 89 (78.9) | 121 (93.3) | 54 (99.8) | 2 (100.0) | 0.12 | 0.5 | |||||
| MR-CoNS (2,155) | 8 (0.4) | 56 (3.0) | 460 (24.3) | 383 (42.1) | 296 (55.8) | 650 (86.0) | 285 (99.2) | 17 (100.0) | 0.25 | 1 | |||||
| Enterococcus spp. (5,519) | 32 (0.6) | 564 (10.8) | 2189 (50.5) | 1594 (79.3) | 856 (94.9) | 251 (99.4) | 30 (99.9) | 2 (>99.9) | 1 (100.0) | 0.06 | 0.25 | ||||
| Vancomycin susceptible (4,456) | 24 (0.5) | 437 (10.3) | 1668 (47.8) | 1331 (77.6) | 755 (94.6) | 221 (99.6) | 17 (99.9) | 2 (>99.9) | 1 (100.0) | 0.12 | 0.25 | ||||
| Vancomycin nonsusceptible (1,063) | 8 (0.8) | 127 (12.7) | 521 (61.7) | 263 (86.5) | 101 (96.0) | 30 (98.8) | 13 (100.0) | 0.06 | 0.25 | ||||||
| Enterococcus faecalis (3,346) | 21 (0.6) | 266 (8.6) | 1032 (39.4) | 1097 (72.2) | 697 (93.0) | 212 (99.4) | 18 (99.9) | 2 (>99.9) | 1 (100.0) | 0.12 | 0.25 | ||||
| Vancomycin susceptible (3,254) | 17 (0.5) | 260 (8.5) | 1010 (39.6) | 1061 (72.2) | 680 (93.1) | 207 (99.4) | 16 (99.9) | 2 (>99.9) | 1 (100.0) | 0.12 | 0.25 | ||||
| Vancomycin nonsusceptible (92) | 4 (4.3) | 6 (10.9) | 22 (34.8) | 36 (73.9) | 17 (92.4) | 5 (97.8) | 2 (100.0) | 0.12 | 0.25 | ||||||
| Enterococcus faecium (1,955) | 8 (0.4) | 269 (14.2) | 1053 (68.0) | 434 (90.2) | 143 (97.5) | 36 (99.4) | 12 (100.0) | 0.06 | 0.12 | ||||||
| Vancomycin susceptible (1,019) | 5 (0.5) | 149 (15.1) | 571 (71.1) | 217 (92.4) | 64 (98.7) | 12 (99.9) | 1 (100.0) | 0.06 | 0.12 | ||||||
| Vancomycin nonsusceptible (936) | 3 (0.3) | 120 (13.1) | 482 (64.6) | 217 (87.8) | 79 (96.3) | 24 (98.8) | 11 (100.0) | 0.06 | 0.25 | ||||||
| Other Enterococcus spp. (218) | 3 (1.4) | 29 (14.7) | 104 (62.4) | 63 (91.3) | 16 (98.6) | 3 (100.0) | 0.06 | 0.12 | |||||||
| Streptococcus pneumoniae (6,253) | 209 (3.3) | 2402 (41.8) | 3105 (91.4) | 426 (98.2) | 88 (99.6) | 23 (100.0) | 0.06 | 0.06 | |||||||
| Penicillin susceptible (≤0.06) (3,747) | 157 (4.2) | 1573 (46.2) | 1724 (92.2) | 237 (98.5) | 46 (99.7) | 10 (100.0) | 0.06 | 0.06 | |||||||
| Penicillin intermediate (≥0.12 and ≤1) (1,040) | 30 (2.9) | 392 (40.6) | 541 (92.6) | 64 (98.8) | 11 (99.8) | 2 (100.0) | 0.06 | 0.06 | |||||||
| Penicillin resistant (≥2) (1,466) | 22 (1.5) | 437 (31.3) | 840 (88.6) | 125 (97.1) | 31 (99.2) | 11 (100.0) | 0.06 | 0.12 | |||||||
| Viridans group streptococci (1,538) | 85 (5.5) | 528 (39.9) | 629 (80.8) | 235 (96.0) | 55 (99.6) | 6 (100.0) | 0.06 | 0.12 | |||||||
| Beta-hemolytic streptococci (3,196) | 8 (0.3) | 740 (23.4) | 1695 (76.4) | 694 (98.2) | 52 (99.8) | 7 (100.0) | 0.06 | 0.12 | |||||||
| Streptococcus pyogenes (1,576) | 3 (0.2) | 547 (34.9) | 898 (91.9) | 114 (99.1) | 11 (99.8) | 3 (100.0) | 0.06 | 0.06 | |||||||
| Streptococcus agalactiae (1,570) | 5 (0.3) | 186 (12.2) | 776 (61.6) | 567 (97.7) | 34 (99.9) | 2 (100.0) | 0.06 | 0.12 | |||||||
| Other beta-hemolytic streptococci (50) | 0 (0.0) | 7 (14.0) | 21 (56.0) | 13 (82.0) | 7 (96.0) | 2 (100.0) | 0.06 | 0.25 | |||||||
| Enterobacteriaceae (20,305) | 0 (0.0) | 1 (<0.1) | 17 (0.1) | 582 (3.0) | 4052 (22.9) | 4840 (46.7) | 5403 (73.4) | 2638 (86.3) | 1191 (92.2) | 846 (96.4) | 511 (98.9) | 224 (100.0) | 2 | 8 | |
| Escherichia coli (8,519) | 0 (0.0) | 15 (0.2) | 561 (6.8) | 3708 (50.3) | 2612 (80.9) | 1167 (94.6) | 376 (99.1) | 69 (99.9) | 9 (>99.9) | 2 (100.0) | 0.5 | 2 | |||
| ESBL-negative Escherichia coli (6,572) | 0 (0.0) | 10 (0.2) | 495 (7.7) | 3171 (55.9) | 1938 (85.4) | 713 (96.3) | 205 (99.4) | 35 (99.9) | 4 (>99.9) | 1 (100.0) | 0.5 | 2 | |||
| ESBL SP phenotype Escherichia coli (1,947) | 0 (0.0) | 5 (0.3) | 66 (3.6) | 537 (31.2) | 674 (65.8) | 454 (89.2) | 171 (97.9) | 34 (99.7) | 5 (99.9) | 1 (100.0) | 1 | 4 | |||
| Klebsiella pneumoniae (4,181) | 0 (0.0) | 1 (<0.1) | 11 (0.3) | 80 (2.2) | 967 (25.3) | 1908 (71.0) | 648 (86.5) | 310 (93.9) | 159 (97.7) | 66 (99.3) | 31 (100.0) | 2 | 8 | ||
| ESBL-negative Klebsiella pneumoniae (2,706) | 0 (0.0) | 1 (<0.1) | 5 (0.2) | 59 (2.4) | 743 (29.9) | 1385 (81.0) | 297 (92.0) | 106 (95.9) | 76 (98.7) | 26 (99.7) | 8 (100.0) | 2 | 4 | ||
| ESBL SP phenotype Klebsiella pneumoniae (1,475) | 0 (0.0) | 6 (0.4) | 21 (1.8) | 224 (17.0) | 523 (52.5) | 351 (76.3) | 204 (90.1) | 83 (95.7) | 40 (98.4) | 23 (100.0) | 2 | 8 | |||
| Klebsiella oxytoca (762) | 0 (0.0) | 3 (0.4) | 21 (3.1) | 440 (60.9) | 212 (88.7) | 44 (94.5) | 30 (98.4) | 11 (99.9) | 1 (100.0) | 1 | 4 | ||||
| Other Klebsiella spp. (94) | 0 (0.0) | 6 (6.4) | 21 (28.7) | 44 (75.5) | 15 (91.5) | 6 (97.9) | 1 (98.9) | 0 (98.9) | 1 (100.0) | 2 | 4 | ||||
| Enterobacter cloacae sp. complex (1,978) | 0 (0.0) | 16 (0.8) | 272 (14.6) | 1057 (68.0) | 417 (89.1) | 98 (94.0) | 63 (97.2) | 42 (99.3) | 13 (100.0) | 2 | 8 | ||||
| Ceftazidime-susceptible Enterobacter cloacae sp. complex (1,356) | 0 (0.0) | 13 (1.0) | 218 (17.0) | 774 (74.1) | 264 (93.6) | 45 (96.9) | 25 (98.7) | 12 (99.6) | 5 (100.0) | 2 | 4 | ||||
| Ceftazidime-nonsusceptible Enterobacter cloacae sp. complex (622) | 0 (0.0) | 3 (0.5) | 54 (9.2) | 283 (54.7) | 153 (79.3) | 53 (87.8) | 38 (93.9) | 30 (98.7) | 8 (100.0) | 2 | 16 | ||||
| Other Enterobacter spp. (658) | 0 (0.0) | 1 (0.2) | 0 (0.2) | 0 (0.2) | 19 (3.0) | 167 (28.4) | 335 (79.3) | 79 (91.3) | 21 (94.5) | 22 (97.9) | 12 (99.7) | 2 (100.0) | 2 | 4 | |
| Citrobacter spp. (816) | 0 (0.0) | 4 (0.5) | 139 (17.5) | 282 (52.1) | 249 (82.6) | 93 (94.0) | 29 (97.5) | 12 (99.0) | 6 (99.8) | 2 (100.0) | 1 | 4 | |||
| Proteus mirabilis (PM) (949) | 0 (0.0) | 4 (0.4) | 10 (1.5) | 44 (6.1) | 169 (23.9) | 372 (63.1) | 259 (90.4) | 91 (100.0) | 16 | 32 | |||||
| Indole-positive Proteus spp. (846) | 0 (0.0) | 8 (0.9) | 42 (5.9) | 189 (28.3) | 281 (61.5) | 164 (80.9) | 93 (91.8) | 69 (100.0) | 8 | 32 | |||||
| Serratia marcescens (1,221) | 0 (0.0) | 15 (1.2) | 274 (23.7) | 687 (79.9) | 170 (93.9) | 30 (96.3) | 30 (98.8) | 15 (100.0) | 4 | 8 | |||||
| Other Serratia spp. (71) | 0 (0.0) | 1 (1.4) | 4 (7.0) | 15 (28.2) | 18 (53.5) | 27 (91.5) | 5 (98.6) | 1 (100.0) | 2 | 4 | |||||
| Salmonella spp. (204) | 0 (0.0) | 1 (0.5) | 2 (1.5) | 56 (28.9) | 36 (46.6) | 87 (89.2) | 18 (98.0) | 2 (99.0) | 2 (100.0) | 2 | 4 | ||||
| Acinetobacter baumannii-Acinetobacter calcoaceticus sp. complex (2,101) | 0 (0.0) | 23 (1.1) | 150 (8.2) | 137 (14.8) | 186 (23.6) | 275 (36.7) | 642 (67.3) | 509 (91.5) | 149 (98.6) | 23 (99.7) | 6 (>99.9) | 1 (100.0) | 2 | 4 | |
| Other Acinetobacter spp. (292) | 1 (0.3) | 1 (0.7) | 13 (5.1) | 69 (28.8) | 67 (51.7) | 27 (61.0) | 28 (70.5) | 32 (81.5) | 41 (95.5) | 13 (100.0) | 0.25 | 4 | |||
| Pseudomonas aeruginosa (2,630) | 0 (0.0) | 1 (<0.1) | 2 (0.1) | 18 (0.8) | 18 (1.5) | 33 (2.7) | 118 (7.2) | 687 (33.3) | 843 (65.4) | 910 (100.0) | 32 | >32 | |||
| Stenotrophomonas maltophilia (604) | 0 (0.0) | 2 (0.3) | 22 (4.0) | 87 (18.4) | 236 (57.5) | 146 (81.6) | 77 (94.4) | 26 (98.7) | 7 (99.8) | 1 (100.0) | 2 | 8 | |||
| Haemophilus influenzae (3,383) | 1 (<0.1) | 7 (0.2) | 106 (3.4) | 1512 (48.1) | 1509 (92.7) | 224 (99.3) | 18 (99.8) | 6 (100.0) | 1 | 1 | |||||
| β-Lactamase-positive Haemophilus influenzae (736) | 0 (0.0) | 18 (2.4) | 292 (42.1) | 371 (92.5) | 52 (99.6) | 3 (100.0) | 1 | 1 | |||||||
| β-lactamase-negative Haemophilus influenzae (2,647) | 1 (<0.1) | 7 (0.3) | 88 (3.6) | 1220 (49.7) | 1138 (92.7) | 172 (99.2) | 15 (99.8) | 6 (100.0) | 1 | 1 | |||||
| Moraxella catarrhalis (1,226) | 174 (14.2) | 782 (78.0) | 225 (96.3) | 40 (99.6) | 5 (100.0) | 0.12 | 0.25 | ||||||||