TABLE 1.
MICs of various antibiotics for ΔcroRS mutants
| Antibiotic | Median MIC (μg/ml)a |
|||
|---|---|---|---|---|
|
E. faecium |
E. faecalis |
|||
| Wild type | ΔcroRS mutant | Wild type | ΔcroRS mutant | |
| Cefadroxil (narrow spectrum) | 64 | 32 | 64 | 32 |
| Cefuroxime (expanded spectrum) | 512 | 64 | 32 | 4 |
| Ceftriaxone (broad spectrum) | 64 | 1 | 64 | 8 |
| Cefepime (fourth generation) | 512 | 4 | 16 | 8 |
| Ampicillin | 1 | 0.25 | 1 | 0.5 |
| Bacitracin | 64 | 8 | 64 | 8 |
| Vancomycin | 0.5 | 0.25 | 2 | 0.5 |
| Chloramphenicol | 4 | 4 | 4 | 4 |
a
Median MICs are reported from ≥2 biological replicates. The strains analyzed were wild-type E. faecalis OG1, E. faecalis ΔcroRS mutant SB35, wild-type E. faecium 1,141,733, and E. faecium ΔcroRS mutant JL537.