FIG 4.
In vivo dose effect of omadacycline against select S. pneumoniae strains using a neutropenic murine pneumonia model. Each symbol represents the mean result from three mice. Five total drug dose levels were fractionated into an every-12-h regimen. The omadacycline exposure is expressed as the plasma 24 h AUC/MIC. The burden of organisms was measured at the start and end of therapy. The study period was 24 h. The horizontal dashed line at 0 represents the burden of organisms in the lungs of mice at the start of therapy. Data points below the line represent cidal activity and points above the line represent net growth. The R2 represents the coefficient of determination. The line drawn through the data points is the best-fit line based upon the sigmoid Emax formula.