TABLE 3.
Exposure to RIcT of atovaquone-resistant P. berghei isolates carrying the M133I Qo1 mutation selected by RIaT
| M133I-carrying mutant population | Isolate | No. of cycles to resistance | Mutation(s) detected after RIcTa |
||
|---|---|---|---|---|---|
| Qo1 | Qo2 | Tm VI | |||
| Homogenous mutant population | PbLASNL1.1 | 2 | M133I | T273P | |
| PbLASNL1.2 | 2 | M133I | K272R | ||
| PbLASNL1.3 | 3 | M133I | G280D | ||
| PbLASNL1.4 | 2 | M133I | G280D | ||
| PbLASNL1.5 | 2 | M133I | G280D | ||
| PbLASNL1.6 | 2 | M133I | G280D | ||
| PbLASNL1.7 | 2 | M133I | G280D | ||
| Mixed mutant–wild-type population | PbLASNL4.1 | 3 | M133I + T139N | ||
| PbLASNL4.2 | 4 | M133I + V140A | |||
| PbLASNL4.3 | 3 | M133I + V140A | |||
| PbLASNL4.4 | 5 | M133I + L144Y | |||
| PbLASNL4.5 | 5 | M133I | T273P | ||
| PbLASNL4.6 | 3 | M133I | L271V + K272V | ||
| PbLASNL4.7 | 4 | T139N | V284F | ||
| PbLASNL4.8 | 5 | L271F | V284F | ||
| PbLASNL4.9 | 2 | L271V + K272R | |||
| PbLASNL4.10 | 3 | L271V + K272R | |||
a
Tm, transmembrane.