TABLE 2.

Drug concentrations at 2 h postdosing in different groups of patients^a

Characteristic	No. (%) of patients	Median (IQR) concn (μg/ml)
		RMP	INH	PZA
Sex
Male	1,291 (68)	2.3 (0.7–4.8)	7.4 (4.5–11.0)	32.3 (23.7–40.5)
Female	621 (32)	2.3 (0.6–5.4)	7.7 (4.4–11.4)	35.1 (24.9–45.4)
P value		0.470	0.235	<0.001
Age (yr)
18–59	1,754 (92)	2.3 (0.6–4.9)	7.4 (4.4–10.9)	33.3 (23.9–41.4)
>60	158 (8)	2.8 (1.0–6.0)	9.0 (5.5–12.0)	36.9 (24.5–44.9)
P value		0.033	<0.001	0.038
Smoker
Yes	612 (32)	2.3 (0.7–4.8)	7.8 (5.0–11.0)	33.3 (25.3–40.8)
No	1,300 (68)	2.3 (0.6–5.0)	7.4 (4.3–11.0)	33.5 (23.5–42.0)
P value		0.844	0.072	0.733
Alcohol user
Yes	742 (39)	2.3 (0.7–4.7)	7.7 (4.9–11.1)	33.5 (25.0–41.5)
No	1,170 (61)	2.3 (0.6–5.1)	7.4 (4.2–11.0)	33.5 (23.5–42.0)
P value		0.590	0.232	0.953
Smear statusb
Positive	887 (71)	2.3 (0.6–4.9)	7.9 (4.7–11.3)	34.5 (24.1–42.3)
Negative	354 (29)	2.4 (0.8–5.3)	7.7 (4.9–11.4)	33.4 (24.9–43.0)
P value		0.340	0.938	0.913
Diabetes
Yes	452 (24)	2.3 (0.7–4.9)	6.6 (3.9–9.8)	31.0 (22.3–38.0)
No	1,460 (76)	2.3 (0.6–5.0)	7.8 (4.7–11.3)	34.1 (24.6–42.7)
P value		0.858	<0.001	<0.001
Baseline INH susceptibilityc
Sensitive	598 (92)	2.2 (0.6–4.8)	8.0 (4.6–11.3)	34.5 (24.1–42.8)
Resistant	53 (8)	2.6 (0.5–5.8)	9.0 (5.7–11.4)	37.9 (29.1–44.0)
P value		0.376	0.442	0.127
Body wt (kg)
≤48	961 (50)	2.3 (0.7–5.2)	8.4 (5.0–12.0)	37.6 (25.3–46.0)
>48	951 (50)	2.3 (0.6–4.8)	6.8 (4.0–9.7)	30.6 (23.0–37.1)
P value		0.1681	<0.001	<0.001
Disease
PTB	1,241 (65)	2.3 (0.6–5.0)	7.9 (4.7–11.3)	34.1 (24.4–42.6)
EPTB	671 (35)	2.3 (0.6–5.0)	7.0 (4.0–10.2)	32.2 (23.5–39.8)
P value		0.981	0.001	0.003
Category of ATT
I	1,659 (87)	2.3 (0.7–5.0)	7.4 (4.6–11.0)	33.4 (24.3–41.6)
II	253 (13)	2.2 (0.6–4.9)	7.8 (4.0–11.4)	33.7 (20.5–42.3)
P value		0.960	0.780	0.487

^aData are for 1,912 patients unless indicated otherwise.

^bData are only for pulmonary TB patients (n = 1,241).

^cData are only for culture-positive cases (n = 651).