TABLE 3.

Factors influencing drug concentrations^a

Type of analysis and factor	RMP			INH			PZA
	β	95% CI	P value	β	95% CI	P value	β	95% CI	P value
Univariate analysis
Gender	−0.334	−0.664 to −0.005	0.047	−0.311	−0.746 to 0.123	0.160	−2.779	−4.115 to −1.442	<0.001
Age	0.015	0.004 to 0.027	0.007	0.036	0.022 to 0.051	<0.001	0.052	0.006 to 0.098	0.026
Smoker	−0.083	−0.414 to 0.248	0.621	0.294	−0.142 to 0.730	0.186	−0.298	−1.646 to 1.050	0.664
Alcohol user	−0.175	−0.492 to 0.142	0.279	0.175	−0.242 to 0.593	0.411	−0.071	−1.362 to 1.219	0.914
Smear status	−0.150	−0.514 to 0.214	0.420	0.141	−0.349 to 0.630	0.573	−0.426	−1.925 to 1.074	0.578
Diabetes mellitus	−0.092	−0.456 to 0.271	0.619	−0.960	−1.437 to −0.483	<0.001	−3.255	−4.727 to −1.783	<0.001
Body wt	−0.016	−0.029 to −0.002	0.025	−0.074	−0.102 to −0.067	<0.001	−0.281	−0.335 to −0.227	<0.001
Baseline INH susceptibilityb	NA	NA	NA	0.699	−0.584 to 1.982	0.285	NA	NA	NA
Type of TB	0.002	−0.322 to 0.325	0.992	0.789	0.364 to 1.215	<0.001	1.668	0.353 to 2.984	0.013
Category of ATT	0.080	−0.375 to 0.536	0.730	0.024	−0.577 to 0.625	0.938	−1.150	−3.004 to 0.705	0.224
Drug dose	0.175	0.078 to 0.271	<0.001	0.398	0.322 to 0.473	<0.001	0.520	0.428 to 0.613	<0.001
Multivariate analysis
Gender	−0.442	−0.782 to −0.102	0.011	NA	NA	NA	−3.161	−4.499 to −1.823	<0.001
Age	0.020	0.009 to 0.032	<0.001	0.051	0.036 to 0.066	<0.001	0.122	0.073 to 0.170	<0.001
Diabetes mellitus	NA	NA	NA	−1.006	−1.511 to −0.501	<0.001	−2.676	−4.233 to −1.119	0.001
Body wt	NS	NS	NS	NS	NS	NS	NS	NS	NS
Type of TB	NA	NA	NA	NS	NS	NS	NS	NS	NS
Drug dose	0.171	0.075 to 0.268	<0.001	0.375	0.298 to 0.451	<0.001	0.482	0.387 to 0.576	<0.001

^aNS, not significant; NA, not applicable; β, regression coefficient, which indicates the change per 1 unit.

^bThis factor was tested against INH concentrations only.