TABLE 4.
Factors associated with treatment outcome
| Factor | Outcomea: |
ORb (95% CI) | P value for OR | aOR (95% CI) | P value for aOR | |
|---|---|---|---|---|---|---|
| Favorable | Unfavorable | |||||
| Sex | ||||||
| Male | 1,056 (64.1) | 235 (89) | 4.54 (3.05–6.76) | <0.001 | 1.92 (1.02–3.62) | 0.043 |
| Female | 592 (35.9) | 29 (11) | Reference | Reference | ||
| Age (yr) | ||||||
| 18–59 | 1,519 (92.2) | 235 (89) | Reference | 0.085 | NSc | NS |
| ≥60 | 129 (7.8) | 29 (11) | 1.45 (0.95–2.22) | NS | NS | |
| Smoker | ||||||
| No | 1,172 (71.1) | 128 (48.5) | Reference | <0.001 | NS | NS |
| Yes | 476 (28.9) | 136 (51.5) | 2.62 (2.01–3.41) | NS | NS | |
| Alcohol user | ||||||
| No | 1,077 (65.4) | 93 (35.2) | Reference | <0.001 | Reference | <0.001 |
| Yes | 571 (34.6) | 171 (64.8) | 3.47 (2.64–4.55) | 2.17 (1.42–3.31) | ||
| Smear statusd | ||||||
| Negative | 515 (42.4) | 59 (24) | Reference | <0.001 | NS | NS |
| Positive | 700 (57.6) | 187 (76) | 2.33 (1.7–3.19) | NS | NS | |
| Diabetes | ||||||
| No | 1,251 (75.9) | 209 (79.2) | Reference | 0.248 | NS | NS |
| Yes | 397 (24.1) | 55 (20.8) | 0.83 (0.6–1.14) | NS | NS | |
| Baseline INH susceptibilitye | ||||||
| Sensitive | 687 (96.5) | 147 (84) | Reference | <0.001 | Reference | <0.001 |
| Resistant | 25 (3.5) | 28 (16) | 5.23 (2.97–9.24) | 5.74 (3.12–10.59) | ||
| Body wt (kg) | 49 (42–56) | 45 (40–50) | 0.96 (0.95–0.97) | <0.001 | 0.96 (0.94–0.98) | <0.001 |
| Disease | ||||||
| EPTB | 637 (38.7) | 34 (12.9) | Reference | <0.001 | NS | NS |
| PTB | 1,011 (61.3) | 230 (87.1) | 4.26 (2.93–6.19) | NS | NS | |
| Category | ||||||
| I | 1,464 (88.8) | 195 (73.9) | Reference | <0.001 | Reference | <0.001 |
| II | 184 (11.2) | 69 (26.1) | 2.82 (2.06–3.86) | 2.39 (1.56–3.65) | ||
| Concn (μg/ml) at 2 h postdosing | ||||||
| RMP | 2.3 (0.7–5) | 2.1 (0.5–4.4) | 0.97 (0.93–1.01) | 0.140 | 0.94 (0.89–0.99) | 0.036 |
| INH | 7.4 (4.5–10.9) | 8.4 (4.7–11.8) | 1.02 (0.99–1.05) | 0.116 | NS | NS |
| PZA | 33.3 (24–41.5) | 35.8 (23.7–42.5) | 0.99 (0.98–1.01) | 0.726 | NS | NS |
a
Data represent the number (percent) of patients for all factors except body weight and the concentration at 2 h postdosing, for which the data represent the median (IQR).
b
OR, odds ratio.
c
NS, not significant.
d
Data are only for pulmonary TB patients (n = 1,241).
e
Data are only for culture-positive cases (n = 651).