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. 2017 Apr 25;8:213. doi: 10.3389/fphar.2017.00213

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Copyright © 2017 Baselet, Belmans, Coninx, Lowe, Janssen, Michaux, Tabury, Raj, Quintens, Benotmane, Baatout, Sonveaux and Aerts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Irradiation induces endothelial DNA damage signaling. Graphs represent the amount of γH2AX (A), TP53BP1 (B) and colocalized γH2AX/TP53BP1 (C) foci 30 min, 1, 4, and 24 h after irradiation with a single X-ray dose of 0.05, 0.1, 0.5 and 2 Gy (n = 6). Data show means ± SEM. ^*P < 0.05, ^†P < 0.005, ^‡P < 0.001 compared to sham on the same day, using 2-way ANOVA with Bonferroni post-hoc test. (D) Representative images showing γH2AX (green), TP53BP1 (red) and γH2AX+TP53BP1 (yellow) foci in DAPI stained nuclei (blue) of TICAE cells 30 min after irradiation with a single X-ray dose of 2 Gy.