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Timeline of animal vaccination, infection, and detection. Groups of BALB/c mice (n = 6 per group) were intramuscularly administered with BCG (106CFU) or intranasal inoculation of 106 PFU VSV-846 as single-dose vaccination. For prime-boost approach, mice were first primed with 106 CFU BCG at week 0 and then boosted with 106 PFU VSV-846 at week 12. Immune response detection, BCG challenge, bacterial loads, and pathological detection were applied at indicated time points.
