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. 2017 Apr 25;8:225. doi: 10.3389/fphar.2017.00225

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Copyright © 2017 Pitsilis, Spyridakos, Nomikos and Panagis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rate-frequency functions (rate of lever pressing as a function of stimulation frequency) taken from representative F1 animals. Each plot represents data from a single animal under predrug and drug conditions. Rate frequency functions were obtained by logarithmically decreasing the frequency of the stimulation pulses from a value that sustained maximal lever pressing to one that failed to sustain lever pressing. (A) Mother treatment Δ⁹-THC 0.1 mg/F1 animal treatment Δ⁹-THC 0.1 mg, (B) mother treatment Δ⁹-THC 1 mg/F1 animal treatment Δ⁹-THC 0.1 mg, (C) mother treatment Δ⁹-THC 0.1 mg/F1 animal treatment d-amphetamine 1 mg, and (D) mother treatment Δ⁹-THC 1 mg/F1 animal treatment d-amphetamine 1 mg.