Table 4. Youden-index-based diagnostic sensitivity and specificity obtained from receiver operator characteristic curves in rejection versus HCV+ samples.
| Measure | n | AUC | Sensitivity (n = 28) | Specificity (n = 57) | Threshold at maximum YI | |||
|---|---|---|---|---|---|---|---|---|
| Percent | 95% CI | Percent | 95% CI | Percent | 95% CI | |||
| GcfDNA | 85 | 88.2 | 80.6–95.9 | 75 | 55.1–89.3 | 84.2 | 72.1–92.5 | 23.6% |
| AST | 85 | 76.3 | 65.4–87.2 | 71.4 | 51.3–86.8 | 75.4 | 62.2–85.9 | 82 U/l |
| ALT | 85 | 83 | 72.8–93.2 | 64.3 | 44.1–81.4 | 89.5 | 78.5–96.0 | 132 U/l |
| γ-GT | 85 | 75.3 | 65.1–85.5 | 67.9 | 47.6–84.1 | 71.9 | 58.5–83.0 | 430 U/l |
| Bilirubin | 85 | 68.1 | 55.6–80.6 | 64.3 | 44.1–81.4 | 73.7 | 60.3–84.5 | 22.2 μmol/l |
AUC, area under the curve; GcfDNA, graft-derived cell-free DNA; YI, Youden index.