Table 1. Enrichment score for gene age bins of 500 million years for both COSMIC and OMIM genes.
| Age Factor (MY) | COSMIC | COSMIC Dominant | COSMIC Recessive | ||||||
| Scorea | p-valuea | BSQb | Score | p-value | BSQ | Score | p-value | BSQ | |
| < 500 | 0.49 | 9.26x10-5 | 0.02% | 0.56 | 0.0126 | 0.02% | 0.27 | 0.00196 | 0.02% |
| 500–1000 | 1.32 | 2.49x10-16 | 0.02% | 1.44 | 4.38x10-17 | 0.02% | 1.02 | 0.118 | 81.32% |
| 1000–1500 | 1.31 | 1.05x10-5 | 0.14% | 1.29 | 2.17x10-4 | 0.88% | 1.32 | 0.0625 | 9.96% |
| 1500–2000 | 0.71 | 0.298 | 6.94% | 0.59 | 0.15 | 2.08% | 1.23 | 0.495 | 39.48% |
| 2000–2500 | 0.97 | 0.907 | 81.60% | 0.93 | 1 | 67.42% | 0.96 | 0.931 | 81.44% |
| 2500–3000 | 0.93 | 1 | 64.70% | 0.72 | 0.438 | 15.66% | 1.4 | 0.365 | 23.02% |
| 3000–3500 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| > 3500 | 0.72 | 0.298 | 5.40% | 0.34 | 0.00145 | 0.02% | 1.82 | 0.0395 | 2.14% |
| Age Factor (MY) | OMIM | OMIM Dominant | OMIM Recessive | ||||||
| Score | p-value | BSQ | Score | p-value | BSQ | Score | p-value | BSQ | |
| < 500 | 0.38 | 2.90x10-4 | 0.02% | 0.51 | 0.177 | 0.30% | 0.26 | 7.51x10-4 | 0.02% |
| 500–1000 | 1.32 | 5.46x10-8 | 0.12% | 1.28 | 7.54x10-4 | 4.34% | 1.36 | 4.72x10-5 | 0.54% |
| 1000–1500 | 0.91 | 0.781 | 44.86% | 0.92 | 0.781 | 60.84% | 0.9 | 0.781 | 52.28% |
| 1500–2000 | 1.18 | 0.566 | 39.40% | 1.33 | 0.566 | 27.66% | 1.04 | 0.781 | 71.66% |
| 2000–2500 | 1.18 | 0.566 | 37.76% | 1.19 | 0.689 | 44.62% | 1.17 | 0.689 | 46.78% |
| 2500–3000 | 0.95 | 1 | 77.96% | 0.84 | 1 | 57.98% | 1.04 | 0.781 | 71.64% |
| 3000–3500 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| > 3500 | 1.4 | 0.126 | 6.40% | 1.12 | 0.781 | 56.66% | 1.65 | 0.0873 | 3.86% |
Score indicates the enrichment (> 1) or depletion (< 1) of genes in the age category. Scores that are statistically different from 1 as determined by either the p-value or BSQ are bolded.
a Enrichment and p-values were computed as indicated in Zeeberg, et al. [41] where the enrichment score is the proportion of genes within the list from the category divided by the proportion of all human genes that fall into the category. P-values were computer by Fisher’s exact test and then adjusted for multiple comparisons using the method of Benjamini-Hochenberg as implemented in the p.adjust function of the stats package in R. Scores in bold are have p-values less than 0.05.
b Bootstrap quantile (BSQ) score: for a given gene set, 10,000 random samples of the same size are taken without replacement from the parental list of 19,756 aged human genes and distribution of ages is calculated for each one. The BSQ score for an age group is the percentile quantile in which the actual observed frequency value falls for the corresponding age group in the sampling ensemble. Hence, any BSQ value of less than 1% indicates that the observation is highly unlikely by random sampling.