. 2017 Apr 25;12(4):e0176258. doi: 10.1371/journal.pone.0176258

Table 3. Co-localization of cluster hotspots with evolutionarily important regions for genome rearrangement in normal peripheral blood.

Normal	Hotspots in	Odds Ratio	95% Confidence Interval	p-value
Whole Genome:	HSB	0.3053	0.3012–0.3093	<2.2x10^-16
Whole Genome:	EBR	1.135	1.119–1.152	<2.2x10^-16
Overlapping Genes:	HSB	0.3256	0.3183–0.3331	<2.2x10^-16
Overlapping Genes:	EBR	1.757	1.715–1.800	<2.2x10^-16

The comparison was run looking at private SNVs (determined from trio comparison) clustering across the entire genome as well as clustering that only overlapped genes. HSB, homologous synteny region; EBR, evolutionarily re-used breakpoint region.