Table 4. Consensus identification of the most significant SNPs associated with PA platelet response.

		Stepwise (Jones et al 2009)	RF with Stepwise	RF with Ridge regression	RF with LASSO	RF with Boruta (P = 0.01)	Consensus (3/4)
Platelet response type		PA	PA	PA	PA	PA	PA
SNPs ID	Gene/Location
rs17229705	VAV3	✔ (0.0009)	×	×	×	×
rs3788337	GNAZ	✔ (0.0009)	×	×	×	×
rs5227	PTGS2	✔ (0.01)	×	×	×	×
rs1778614	ITPR1	✔ (0.003)	×	×	×	×
rs246406	ITGA2	✔ (0.002)	×	×	×	×
rs11631474	MAP2K5	✔ (0.007)	×	×	×	×
rs851007	MAPK14	✔ (0.003)	×	×	×	×
rs6141803	COMMD7	×	✔ (0.0033)	×	✔ (0.0006)	✔	✔
rs6442896	ITPR1	× (0.049)	✔ (0.0006)	✔(0.0002)	✔(0.0021)	✔	✔
rs3730051	AKT2	× (0.031)	✔ (0.0002)	✔ (0.0031)	✔ (0.0002)	×	✔
rs1527480	CD36	× (0.449)	✔ (0.0021)	✔(0.0008)	✔ (0.0036)	✔	✔
rs8033381	CSK	× (0.792)	✔ (0.0018)	✔ (0.0082)	✔ (0.0038)	×	✔
rs10061730	ITGA2	× (0.517)	×	×	✔ (0.0005)	×
rs2292867	ITGB3	×(0.039)	×	✔ (0.017)	✔ (0.0080)	×
rs2300065	SKP1		×	✔(0.0138)	✔(0.0164)	×
rs3212391	ITGA2	×	✔ (0.0002)	×	×	✔
rs6433658	ITPR1	×	×	×	×	✔
rs6442895	ITPR1	×(0.029)	×	×	×	✔
rs17041401	ITPR1	✔(0.003)	×	×	×	✔
rs3212386	ITGA2	×(0.378)	×	×	×	✔
rs33443	ITGA2	×(0.547)	×	×	×	✔
rs26682	ITGA2	×(0.126)	×	×	×	✔
rs3212418	ITGA2	✔(0.013)	×	×	×	✔
rs11742558	ITGA2	×(0.713)	×	×	×	✔
rs7568033	NFE2L2	×	×	×	×	✔

We select the consensus SNP if it has been identified by at least three methods, which means it has higher significance and hence is more likely to be a key genetic variant.

× indicates either the SNP was not identified by the method or previously identified as insignificant

✔ indicates the SNP was identified by the method.

Numbers inside the brackets after ✔ or × indicate p values of the SNPs calculated using Wald test, or partial F-test.