Table 5. Consensus identification of the most significant SNPs associated with FA platelet response.

		Stepwise (Jones et al 2009)	RF with Stepwise	RF with Ridge regression	RF with LASSO	RF with Boruta (P = 0.01)	Consensus (3/4)
Platelet response type		FA	FA	FA	FA	FA	FA
SNPs ID	Gene/Location
rs11637556	MAP2K1	✔ (0.005)	✔ (0.0007)	✔ (0.0083)	✔ (0.0008)	✔	✔
rs10429491	JAK2	✔ (0.0006)	×	×	×	×
rs3729931	RAF1	✔ (0.0001)	×	×	×	×
rs41305896	ITGA2	✔ (0.001)	×	×	×	×
rs350916	MAP2K2	✔ (0.001)	×	×	×	×
rs17786144	ITPR1	✔ (0.002)	×	×	×	×
rs11264579	PEAR1	✔ (0.004)	×	×	×	×
rs41304345	MADD	✔ (0.003)	×	×	×	×
rs1388622	P2RY12	× (0.058)	✔ (0.0001)	×	×	✔
rs2071676	CA9	×	✔ (0.0122)	✔(0.0058)	✔(0.0098)	✔	✔
rs1491978	P2RY12	× (0.092)	×	×	✔(0.0003)	✔
rs1537593	CD36	× (0.731)	×	×	✔(0.0058)	✔
rs9895150	ITGB3	× (0.177)	×	✔(0.0193)	✔(0.0141)	×
rs1038639	ITPR1	× (0.138)	×	✔(0.0019)	✔(0.0006)	✔	✔
rs10499858	CD36	× (0.129)	✔ (0.0012)	×	×	✔
rs7034539	JAK2	× (0.061)	✔ (0.0053)	✔(0.0058)	✔(0.0077)	×	✔
rs3742633	PRKCH	× (0.985)	✔ (0.0172)	×	✔(0.0075)	×
rs41282607	MAPK1	× (0.2)	✔(0.0113)	✔(0.0034)	✔(0.0087)	✔	✔
rs41305272	MAP2K5	× (0.955)	×	✔(0.0127)	✔(0.01)	✔	✔
rs7180408	GTF2A2	×	×	✔(0.0191)	×	×
rs3736101	MADD	✔(0.015)	×	×	✔(0.0076)	×
rs304076	ITPR1	× (0.395)	×	×	✔(0.0083)	×
rs17204437	P2Y12	× (0.499)	×	×	✔(0.001)	✔
rs6787801	P2Y12	× (0.448)	×	×	×	✔
rs3173798	CD36	× (0.085)	×	×	×	✔

We select the consensus SNP if it has been identified by at least three methods, which means it has higher significance and hence is more likely to be a key genetic variant.

× indicates either the SNP was not identified by the method or previously identified as insignificant.

✔ indicates the SNP was identified by the method.

Numbers inside the brackets after ✔ or × indicate p values of the SNPs calculated using Wald test, or partial F-test.