Table 3. Main results of meta-analysis.

Outcome	Variables	No. of studies	Heterogeneity		Fixed-effects model		Random-effects model		Meta-regression
			I2(%)	PH	HR (95%CI)	p	HR (95%CI)	p	p
OS	All	8	7.3	0.374	1.84(1.52–2.22)	<0.001	1.85(1.52–2.26)	<0.001
	Ethnicity								0.424
	Asian	6	0	0.479	1.98(1.55–2.54)	<0.001	1.98(1.55–2.54)	<0.001
	Non-Asian	2	54.9	0.136	1.66(1.24–2.22)	0.001	1.72(1.1–2.69)	0.017
	Sample size								0.264
	<200	4	12.5	0.33	2.37(1.52–3.72)	<0.001	2.45(1.49–4.02)	<0.001
	≥200	4	0	0.458	1.74(1.41–2.14)	<0.001	1.74(1.41–2.14)	<0.001
	Cut-off								0.326
	≤3	5	2.9	0.39	2.04(1.57–2.67)	<0.001	2.05(1.56–2.7)	<0.001
	>3	3	10	0.329	1.65(1.27–2.16)	<0.001	1.67(1.25–2.21)	<0.001
PFS	All	7	36.9	0.147	1.64(1.36–1.98)	<0.001	1.69(1.32–2.15)	<0.001
	Ethnicity								0.059
	Asian	6	0	0.612	1.5(1.23–1.84)	<0.001	1.5(1.23–1.84)	<0.001
	Non-Asian	1	-	-	2.98(1.78–4.98)	<0.001	2.98(1.78–4.98)	<0.001
	Sample size								0.564
	<200	3	0	0.756	1.88(1.3–2.71)	0.001	1.88(1.3–2.71)	0.001
	≥200	4	63.6	0.041	1.57(1.26–1.95)	<0.001	1.61(1.11–2.33)	0.011
	Cut-off								0.083
	≤3	5	0	0.526	1.47(1.18–1.82)	<0.001	1.47(1.18–1.82)	<0.001
	>3	2	39.5	0.199	2.39(1.62–3.51)	<0.001	2.35(1.43–3.88)	0.001