TABLE 3.
ORs for dichotomous outcomes by quartiles of baseline mean striatal binding
| Number of Subjects | Outcome Rate (%) | P Value for Trend | ORs (95% CI)
|
||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||||
| MMSE <24 | 491 | 19 (3.9) | 0.0293 | 7.6 (0.8, 68.4) | 5.8 (0.6, 51.7) | 2.3 (0.2, 26.7) | 1 |
| MoCA <26 | 489 | 137 (28.0) | 0.0002 | 3.3 (1.7, 6.7) | 1.7 (0.9, 3.4) | 1.4 (0.7, 2.8) | 1 |
| Psychosis | 491 | 34 (6.9) | 0.0002 | 12.9 (2.6, 62.4) | 6.4 (1.3, 30.9) | 3.0 (0.6, 16.3) | 1 |
| GDS >=5 | 490 | 97 (19.8) | 0.0056 | 2.8 (1.3, 5.7) | 1.8 (0.9, 3.6) | 1.4 (0.7, 2.8) | 1 |
| Postural instability | 488 | 37 (7.6) | 0.0018 | 4.9 (1.6, 15.2) | 2.0 (0.7, 6.4) | 0.9 (0.2, 3.3) | 1 |
| Falling | 490 | 60 (12.2) | 0.0089 | 2.2 (0.9, 5.1) | 1.7 (0.7, 3.7) | 0.4 (0.1, 1.2) | 1 |
| QoL decline | 489 | 122 (25.0) | 0.0537 | 1.8 (0.9, 3.4) | 1.3 (0.7, 2.4) | 0.9 (0.5, 1.8) | 1 |
| S/E ADL decline ≥ 15 | 490 | 67 (13.7) | 0.0066 | 2.8 (1.2, 6.3) | 1.1 (0.5, 2.5) | 0.7 (0.3, 1.6) | 1 |
ORs (95% CIs) from separate logistic regressions adjusted for age, gender, duration of disease, and PreCEPT study treatment, as well as for use of DAAs and/or L-dopa at most recent visit. S/E ADL analysis was also adjusted for baseline S/E ADL. Mean values for quartiles are shown in Table 2. The highest quartile (4) is the reference category.