. Author manuscript; available in PMC: 2017 Apr 25.

Published in final edited form as: Mov Disord. 2012 Sep 13;27(11):1392–1397. doi: 10.1002/mds.25157

TABLE 4.

Estimated differences in continuous outcomes by quartiles of baseline mean striatal binding

		Number of Subjects	P Value for Trend	Estimated Differences (95% CI)
		Number of Subjects	P Value for Trend	Q1	Q2	Q3	Q4
MMSE	↓	491	0.0067	−0.9 (−1.6, −0.3)	−0.3 (−0.9, 0.3)	−0.2 (−0.8, 0.4)	0
MoCA	↓	489	<0.0001	−1.9 (−2.9, −1.0)	−0.6 (−1.5, 0.3)	−0.1 (−0.9, 0.8)	0
UPDRS motor	↑	487	<0.0001	7.1 (4.1, 10.1)	2.1 (−0.8, 4.9)	1.7 (−1.1, 4.4)	0
UPDRS ADL	↑	489	<0.0001	3.3 (1.7, 4.9)	1.3 (−0.2, 2.9)	0.3 (−1.2, 1.7)	0

Parameter estimates (95% CIs) from separate multiple regressions adjusted for age, gender, duration of disease, and PreCEPT study treatment, as well as for use of DAAs and/or L-dopa at most recent visit (or assessment). Arrow indicates direction of worsening. Mean values for quartiles are shown in Table 2. The highest quartile is the reference category.