TABLE 5.

ORs for dichotomous outcomes by quartiles of annual percentage change in mean striatal binding

	Number of Subjects	Outcome Rate (%)	P Value for Trend	ORs (95% CI)
				Q1	Q2	Q3	Q4
MMSE <24	461	19 (4.1)	0.0385	5.4 (1.2, 23.7)	0.4 (0.0, 4.6)	2.1 (0.4, 10.3)	1
MoCA <26	459	129 (28.1)	0.0278	2.1 (1.1, 3.9)	1.3 (0.7, 2.6)	1.2 (0.6, 2.3)	1
Psychosis	461	32 (6.9)	0.0018	6.4 (1.9, 21.3)	2.5 (0.7, 9.3)	2.4 (0.6, 8.7)	1
GDS >=5	460	90 (19.6)	0.1304	1.6 (0.8, 3.2)	2.0 (1.0, 4.0)	1.3 (0.7, 2.8)	1
Postural instability	459	35 (7.6)	0.5030	1.4 (0.5, 3.7)	0.8 (0.3, 2.5)	0.8 (0.3, 2.3)	1
Falling	460	57 (12.4)	0.0485	2.1 (0.9, 5.3)	3.0 (1.2, 7.1)	1.7 (0.7, 4.1)	1
QoL decline	459	113 (24.6)	0.4453	1.2 (0.7, 2.4)	1.5 (0.8, 2.9)	1.3 (0.7, 2.5)	1
S/E ADL decline ≥ 15	460	63 (13.7)	<0.0001	6.5 (2.4, 17.8)	6.1 (2.3, 16.7)	2.6 (0.9, 7.5)	1

ORs (95% CIs) from separate logistic regressions adjusted for baseline mean striatum, age, gender, duration of disease, and PreCEPT study treatment, as well as for use of DAAs and/or L-dopa at most recent visit. S/E ADL analysis was also adjusted for baseline S/E ADL. Mean values for quartiles are shown in Table 2. The highest quartile is the reference category.