TABLE 2.

Association of ANGPTL3 Concentration with MI Risk in PROMIS

	ANGPTL3 Concentration (ng/ml)	Adjusted Odds Ratio for MI (95% CI)
		Model 1*	Model 2†
Tertile 1 (n = 1,575)‡	379–1,375	1.00	1.00
Tertile 2 (n = 1,574)	272–378	0.75 (0.64–0.88)	0.79 (0.66–0.93)
Tertile 3 (n = 1,575)	18–271	0.65 (0.55–0.77)	0.71 (0.60–0.85)
p Value for trend		2.2 x 10−7	0.0001

^*Sex, current smoking, diabetes, and hypertension as covariates.

^†Model 1 plus LDL cholesterol and log-transformed triglycerides as covariates.

^‡Individuals with the highest tertile of ANGPTL3 concentration served as the reference group for this analysis.

MI = myocardial infarction; other abbreviations as in Table 1.