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. 2017 Apr 18;23:1857–1871. doi: 10.12659/MSM.900030

Table 4.

GO functional annotation for the significant targets of miR-101-3p as determined by DAVID.

GO ID GO term Count (%) P value Gene symbol
Biological process
GO: 0010629 Negative regulation of gene expression 31 (0.4) 6.89×10−6 GCLC, THRB, CBX4, ZEB2, ZEB1, SOX9, PRDM16, LIN28B etc.
GO: 0006357 Regulation of transcription from RNA polymerase ii promoter 39 (0.5) 8.52×10−6 THRB, MITF, CBX4, ZEB1, PRDM16, SOX9, MED20, FOS etc.
GO: 0010604 Positive regulation of macromolecule metabolic process 43 (0.6) 1.36×10−5 GCLC, THRB, MITF, ZEB1, PRDM16, SOX9, FOS, APP, MEIS2 etc.
GO: 0009891 Positive regulation of biosynthetic process 37 (0.5) 1.83×10−5 THRB, MITF, ZEB1, ABCA1, PRDM16, SOX9, FOS, APP etc.
GO: 0006325 Chromatin organization 25 (0.4) 2.10×10−5 EZH2, NAP1L1, CBX4, CDYL, H2AFV, SMARCD1 etc.
GO: 0051173 Positive regulation of nitrogen compound metabolic process 35 (0.5) 2.15×10−5 THRB, MITF, ZEB1, ABCA1, PRDM16, SOX9, FOS, APP etc.
GO: 0031328 Positive regulation of cellular biosynthetic process 36 (0.5) 3.20×10−5 THRB, MITF, ZEB1, ABCA1, PRDM16, SOX9, FOS, APP etc.
GO: 0008284 Positive regulation of cell proliferation 26 (0.4) 3.24×10−5 NRP1, PTGS2, MARCKSL1, NAP1L1, CD47, AGGF1, TGFA etc.
GO: 0016568 Chromatin modification 20 (0.3) 4.74×10−5 DNMT3A, AEBP2, UBE2A, EZH2, CBX4, ARID1A, RBBP7, UBE2B etc.
GO: 0042127 Regulation of cell proliferation 39 (0.6) 4.94×10−5 NRP1, PTGS2, MARCKSL1, MITF, NAP1L1, ZEB1, SOX9, CDH5 etc.
Cellular component
GO: 0005626 Insoluble fraction 43 (0.6) 3.83×10−7 GALNT3, GNAI3, PTGS2, PLXNA1, HMGCR, SGPP1, ADCY6 etc.
GO: 0000267 Cell fraction 49 (0.7) 1.78×10−6 RAB3GAP2, PLXNA1, PTGS2, HMGCR, SGPP1, ADCY6, SLC26A2 etc.
GO: 0005624 Membrane fraction 40 (0.6) 2.65×10−6 GALNT3, GNAI3, PTGS2, PLXNA1, HMGCR, SGPP1, ADCY6 etc.
GO: 0005694 Chromosome 28 (0.4) 3.14×10−6 HMGB3, CBX4, CDYL, SIN3A, H2AFV, PAFAH1B1, CHD6, TOP2B etc.
GO: 0044427 Chromosomal part 25 (0.4) 4.29×10−6 CBX4, CDYL, SIN3A, H2AFV, PAFAH1B1, TOP2B, CHD6 etc.
GO: 0000785 Chromatin 17 (0.2) 8.35×10−6 DNMT3A, UBE2A, PDS5B, CBX4, HMGA2, UBE2B, JUNB, MYCN etc.
GO: 0009898 Internal side of plasma membrane 21 (0.3) 2.14×10−5 RAP2C, RAB39B, AP1G1, MAOB, PIP5K1C, SNAPIN, CTNNA1 etc.
GO: 0019898 Extrinsic to membrane 27 (0.4) 3.26×10−5 PTGS2, CHMP5, ARHGAP17, MTMR2, DMXL2, PVRL1, RAC1 etc.
GO: 0031974 Membrane-enclosed lumen 65 (0.9) 1.10×10−4 MRPL42, PTGS2, ZMAT3, ATP5B, EZH2, DNAJC10, ZEB1 etc.
GO: 0043233 Organelle lumen 64 (0.9) 1.13×10−4 MRPL42, PTGS2, ZMAT3, ATP5B, EZH2, DNAJC10, ZEB1, WTAP etc.
Molecular function
GO: 0008134 Transcription factor binding 33 (0.5) 2.25×10−6 THRB, CBX4, ZEB1, PRDM16, CBFA2T2, RAB1A, TMF1 etc.
GO: 0000166 Nucleotide binding 85 (1.2) 7.96×10−5 CPEB2, HMGCR, ATP5B, UBE2G1, ADCY6, PIP5K1C, HELZ etc.
GO: 0046332 SMAD binding 8 (0.1) 1.41×10−4 FOS, TGFBR1, ZEB2, SMAD2, SMAD1, PRDM16, PURB, PURA
GO: 0003690 Double-stranded DNA binding 11 (0.2) 1.66×10−4 KLF6, FOS, ANKRD17, THRB, SMAD2, ZEB1, PURB etc.
GO: 0030528 Transcription regulator activity 60 (0.9) 4.17×10−4 THRB, ELF5, EZH2, MITF, CBX4, ZEB2, ZEB1, LASS6, CBFA2T2 etc.
GO: 0003682 Chromatin binding 13 (0.2) 4.22×10−4 ATRX, SUZ12, DNMT3A, CDYL, EZH2, MITF, SMARCA5, CBX4 etc.
GO: 0003702 RNA polymerase II transcription factor activity 17 (0.2) 4.79×10−4 CEBPA, RXRB, MITF, TEAD3, SMAD1, SOX9, MED20, MEIS1 etc.
GO: 0032553 Ribonucleotide binding 68 (1.0) 1.02×10−3 UBE2G1, ATP5B, ADCY6, PIP5K1C, HELZ, RAB1A, ANKRD17 etc.
GO: 0032555 Purine ribonucleotide binding 68 (1.0) 1.02×10−3 UBE2G1, ATP5B, ADCY6, PIP5K1C, HELZ, RAB1A, ANKRD17 etc.
GO: 0043566 Structure-specific DNA binding 12 (0.2) 1.13×10−3 KLF6, FOS, ANKRD17, THRB, SUB1, SMAD2, ZEB1, PURB etc.