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. 2017 Apr 25;12(4):e0176293. doi: 10.1371/journal.pone.0176293

Table 1. Characteristics of wheeze and asthma outcomes in ALSPAC by sex, with follow-up rates at each time-point as a percentage of total cohort size for each sex (total ALSPAC = 7,544 males and 7,155 females).

Age (years) Asthma in last 12 months* Wheeze in last 12 months
N with data
(% follow-up)
n with asthma (% of N) N with data
(% follow-up)
n with wheeze (% of N)
Mother completed
time-points (years)
0.5 Male - - 5884(78.0%) 1759(29.9%)
Female - - 5510(77.0%) 1243(22.6%)
1.5 Male - - 5662(75.1%) 1744(30.8%)
Female - - 5291(73.9%) 1272(24.0%)
2.5 Male - - 5157(68.4%) 1321(25.6%)
Female - - 4812(67.3%) 936(19.5%)
3.5 Male - - 5166(68.5%) 1000(19.4%)
Female - - 4817(67.3%) 757(15.7%)
4.8 Male - - 4862(64.4%) 1038(21.3%)
Female - - 4528(63.3%) 739(16.3%)
5.8 Male - - 4429(58.7%) 767(17.3%)
Female - - 4156(58.1%) 561(13.5%)
6.8 Male 4365(57.9%) 609(14.0%) 4315(57.2%) 646(15.0%)
Female 4125(57.7%) 454(11.0%) 4071(56.9%) 481(11.8%)
7.6 Male 4215(55.9%) 568(13.5%) 4220(55.9%) 531(12.6%)
Female 3984(55.7%) 387(9.7%) 3989(55.8%) 353(8.8%)
8.6 Male 4179(55.4%) 572(13.7%) 4172(55.3%) 629(15.1%)
Female 4033(56.4%) 402(10.0%) 4024(56.2%) 427(10.6%)
10.7 Male 3914(51.9%) 545(13.9%) 3850(51.0%) 568(14.8%)
Female 3864(54.0%) 389(10.1%) 3804(53.2%) 368(9.7%)
11.7 Male - - 3693(49.0%) 509(13.8%)
Female - - 3710(51.9%) 363(9.8%)
13.1 Male 3492(46.3%) 473(13.5%) 3486(46.2%) 431(12.4%)
Female 3526(49.3%) 360(10.2%) 3518(49.2%) 311(8.8%)
13.8 Male 3537(46.9%) 452(12.8%) 3476(46.1%) 427(12.3%)
Female 3507(49.0%) 366(10.4%) 3464(48.4%) 338(9.8%)
16.5 Male - - 2736(36.3%) 286(10.5%)
Female - - 2905(40.6%) 307(10.6%)
Child completed
time-points (years)
16.5 Male 2055(27.2%) 245(11.9%) 2047(27.1%) 353(17.2%)
Female 2968(41.5%) 374(12.6%) 2960(41.4%) 668(22.6%)
18.6 Male - - 1189(15.8%) 185(15.6%)
Female - - 2162(30.2%) 470(21.7%)

*Questions on asthma in the last 12 months were not included in ALSPAC questionnaires between the ages of 6 months and 5.8 years, at 11.5 years and at 18.6 years.