Table 1. Large-scale gene expression changes at three different time points after exposure of S. mansoni schistosomula to the HDAC inhibitor TSA.
| Duration of treatment | |||||
|---|---|---|---|---|---|
| 12 h | 24 h | 48 h | |||
| Expressed Smp genes (in control or treated—or in both conditions) | 8198 | 7916 | 8090 | ||
| Differentially expressed Smp genes compared to untreated controls a (% of total expressed Smps) | 3495 (43%) | 3848 (49%) | 4353 (54%) | ||
| Up-regulated Smp genes | 1695 | 2719 | 1108 | ||
| Down-regulated Smp genes | 1800 | 1129 | 3245 | ||
| Up-regulated Smp genes with histone reader motif | 36 | 77 | 20 | ||
| Down-regulated Smp genes with histone reader motif | 37 | 12 | 65 | ||
| Expressed antisense RNAs (asRNAs) (in control or treated—or in both conditions) | 4516 | 3257 | 3490 | ||
| Differentially expressed asRNAs compared to untreated controls a (% of total expressed asRNAs) | 1506 (33%) | 1376 (42%) | 1559 (45%) | ||
| Up-regulated asRNAs | 1137 | 1193 | 963 | ||
| Down-regulated asRNAs | 369 | 183 | 596 | ||
aStatistically significant differential expression (q-value ≤ 0.05)