Table 2. Gene ontology categories enrichment for differentially expressed genes of schistosomula treated for 12 h with HDAC inhibitor (TSA).
| Gene Ontology Category | GO ID | NSP | p-valuea | Pop. | DEGs |
|---|---|---|---|---|---|
| Genes up-regulated at 12 h treatment with TSA | |||||
| Ciliary part | GO:0044441 | C | 0.0348 | 6 | 5 |
| Phosphorus metabolic process | GO:0006793 | B | 0.0003 | 622 | 164 |
| Cellular protein modification process | GO:0006464 | B | 0.0042 | 408 | 98 |
| Signal transduction | GO:0007165 | B | 0.0076 | 358 | 89 |
| ATP catabolic process | GO:0006200 | B | 0.0127 | 32 | 14 |
| ATP binding | GO:0005524 | M | 0.0067 | 581 | 160 |
| Divalent inorganic cation transmembrane transporter activity | GO:0072509 | M | 0.0228 | 18 | 10 |
| Transferase activity | GO:0016740 | M | 0.0228 | 779 | 201 |
| Genes down-regulated at 12 h treatment with TSA | |||||
| Plasma membrane | GO:0005886 | C | 0.0026 | 67 | 32 |
| Cell surface receptor signaling pathway | GO:0007166 | B | 0.0105 | 122 | 46 |
| Receptor activity | GO:0004872 | M | 0.0028 | 103 | 43 |
| Cation binding | GO:0043169 | M | 0.0128 | 849 | 217 |
NSP, the namespace, or subontology; B, Biological process; C, Cellular component; M, Molecular function; Pop., population number of S. mansoni genes present in the GO category; DEGs, number of differentially expressed genes enriched in the category.
aBenjamini-Hochberg adjusted p-value.