Table 3. Gene ontology categories enrichment for differentially expressed genes of schistosomula treated for 24 h with HDAC inhibitor (TSA).
| Gene Ontology Category | GO ID | NSP | p-valuea | Pop. | DEGs |
|---|---|---|---|---|---|
| Genes up-regulated at 24 h treatment with TSA | |||||
| Transferase activity, transferring phosphorus-containing groups | GO:0016772 | M | 0.0152 | 454 | 220 |
| ATP binding | GO:0005524 | M | 0.0435 | 572 | 267 |
| DNA replication | GO:0006260 | B | 0.0154 | 51 | 33 |
| Phosphorus metabolic process | GO:0006793 | B | 0.0187 | 610 | 266 |
| Genes down-regulated at 24 h treatment with TSA | |||||
| Cell surface receptor signaling pathway | GO:0007166 | B | 0.0000 | 116 | 45 |
| Molecular transducer activity | GO:0060089 | M | 0.0000 | 114 | 38 |
| Integral component of membrane | GO:0016020 | C | 0.0002 | 537 | 134 |
| Proteolysis | GO:0006508 | B | 0.0003 | 192 | 42 |
| Calcium ion binding | GO:0005509 | M | 0.0014 | 177 | 47 |
| Single-organism process | GO:0044699 | B | 0.0061 | 1198 | 216 |
| Structural constituent of cytoskeleton | GO:0005200 | M | 0.0067 | 12 | 6 |
| Signaling receptor activity | GO:0038023 | M | 0.0088 | 84 | 38 |
| Transporter activity | GO:0005215 | M | 0.0232 | 266 | 56 |
| Plasma membrane | GO:0005886 | C | 0.0324 | 59 | 18 |
| Iron ion binding | GO:0005506 | M | 0.0378 | 22 | 9 |
| O-acyltransferase activity | GO:0008374 | M | 0.0378 | 11 | 5 |
| Microtubule associated complex | GO:0005875 | C | 0.0389 | 56 | 15 |
NSP, the namespace, or subontology; B, Biological process; C, Cellular component; M, Molecular function; Pop., population number of S. mansoni genes present in the GO category; DEGs, number of differentially expressed genes enriched in the category.
aBenjamini-Hochberg adjusted p-value.