Extended Data Table 3.
Clinical and pathological characteristics of human post mortem tissue samples from multiple sclerosis patients and age-matched controls.
| Sex | Age (years) | PMD (hours) | Disease duration (years) | Disease course | FDX |
|---|---|---|---|---|---|
| F | 51 | 10 | 23 | SP | active |
| F | 35 | 9 | 5 | SP | active |
| M | 40 | 27 | 16 | SP | active |
| F | 50 | 22 | 23 | SP | active, chronic inactive |
| F | 42 | 11 | 6 | PP | chronic active |
| F | 34 | 12 | 11 | SP | chronic active |
| F | 59 | 21 | 39 | SP | chronic active |
| F | 59 | 21 | 39 | SP | chronic active |
| F | 53 | 17 | 28 | SP | chronic inactive |
| M | 53 | 13 | 16 | SP | chronic inactive |
| F | 57 | 12 | 19 | SP | chronic inactive |
| M | 82 | 21 | NA | NA | control, unknown |
| M | 35 | 22 | NA | NA | control, carcinoma of the tongue |
| M | 84 | 5 | NA | NA | control, carcinoma of the bladder |
| M | 82 | 21 | NA | NA | control, myelodysplastic syndrome |
Inflammatory staging of subcortical MS lesions was carried out according to established histological criteria: active – presence of MOG+/LFB+ phagocytes and strong microglia activation; early inactive – presence of PAS+ phagocytes and strong microglia activation; late inactive – no macrophages and diffuse microglia activation7–9. Abbreviations: F, female; FDX, functional diagnosis; LFB, Luxol fast blue; M, male; MOG, myelin oligodendrocyte glycoprotein; MS, multiple sclerosis; NA, not applicable; PAS, periodic acid Schiff; PMD, postmortem delay; PP, primary progressive MS; SP, secondary progressive MS.