Extended Data Table 7.

Clinical and pathological characteristics of human post mortem tissue samples from amyotrophic lateral sclerosis patients and age-matched controls.

Sex	Age (years)	PMD (hours)	FDX	Brain Atrophy	Dementia	Brain region
F	67	19	ALS	None	No	Motor cortex
M	67	8	ALS	None	No	Motor cortex
M	56	4	ALS	Severe	No	Motor cortex
F	56	12	Control	None	No	Motor cortex
–	–	–	Control	None	No	Motor cortex
–	–	–	Control	None	No	Motor cortex

Abbreviations: ALS, Amyotophic lateral sclerosis; F, female; FDX, functional diagnosis; M, male; PMD, post mortem delay.