Fig. 3. Pubertal GBX treatment does not alter spine density in post-pubertal α4−/− mice.
A, Representative z-stack images of dendrites from post-pubertal (PND 56) α4−/− mice treated during puberty (PND 35–44) with vehicle (VEH) or the GABA agonist gaboxadol (GBX) at a dose selective for α4βδ GABARs. B, Averaged spine densities for proximal (left) and distal (right) dendrites. Scale, 3 μm; n=12 dendrites/group (proximal); 16 dendrites/group (distal). (Complete statistics reported in Appendix A, Table A.1.)