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. Author manuscript; available in PMC: 2018 Apr 7.
Published in final edited form as: Neuroscience. 2017 Feb 9;347:22–35. doi: 10.1016/j.neuroscience.2017.01.051

Fig. 6. Pubertal treatment with THP or GBX impairs relearning ability in the post-pubertal mouse.

Fig. 6

A–B, Learning/re-learning a spatial location in the multiple placement object recognition task (MPORT). A, Novel position preference for positions 2 and 3. Position 2: ANOVA, F(2,32)=0.49; P=0.62; position 2, ANOVA, F(2,32)=15.48, *P≤0.0001 vs. VEH; n=11–12 mice/group. B, Locomotor activity (ANOVA, F(2,32)=1.06, P = 0.36) and # approaches (ANOVA, F(2,32)=0.28, P = 0.76). C–F, Learning/relearning a spatial location in the active place avoidance (APA) task. C, Number of trials to learning criterion (120 s latency to first entry of shock zone). Zone 1, ANOVA, F(2,26)=10.73, *P≤0.0005 vs. other groups; zone 2, ANOVA, F(2,26)=5.21, *P≤0.05 vs. other groups. GBX, gaboxadol (THIP); VEH, vehicle; THP (3α-OH, 5α-pregnan-20-one) D, E, Average latency to enter shock zone 1 and 2. Acquisition (D), zone 1: ANOVA, F(2,26)=5.54, *P≤0.01; zone 2: ANOVA, F(2,26)=3.63, *P≤0.05. Retention (E), zone 1: ANOVA, F(2,26)=0.17, P=0.85; zone 2: ANOVA, F(2,26)=0.01, P=0.99. F, Locomotor activity (ANOVA, F(2,26)=0.15, P=0.86) and #shocks/entry (ANOVA, F(2,26)=2.87, P=0.07); n=9–10 mice/group.