Table A.1.

Median, upper and lower quartile values and adjusted P values for individual comparisons of spine density (PND 56) after the indicated drug treatments during adolescence (PND 35–44). Statistics were performed using a multi-level model.

Pubertal Drug Administration in WT mice
Group	Variable	N	Lower Quartile	Median	Upper Quartile	P value
GBX	Proximal dendrite spine density	10	3.55	4.43	5.31	0.0177
						0.0003*
	Distal dendrite spine density	8	4.15	7.06	8.70	0.0091
						0.0003*
THP	Proximal dendrite spine density	21	12.00	15.18	16.75	0.0163
	Distal dendrite spine density	23	17.15	20.85	24.64	0.0057
Vehicle	Proximal dendrite spine density	24	6.13	9.19	11.03
	Distal dendrite spine density	19	8.45	10.97	14.66
Pubertal GBX Administration in α4 KO
GBX	Proximal dendrite spine density	11	12.00	13.33	16.00	0.9376
	Distal dendrite spine density	12	13.33	20.00	21.00	0.8807
Vehicle	Proximal dendrite spine density	12	14.77	17.74	22.36
	Distal dendrite spine density	9	15.62	17.61	21.00
Pubertal THP Administration in α4 KO
THP	Proximal dendrite spine density	12	11.33	16.00	19.33	0.3409
	Distal dendrite spine density	12	17.00	18.33	20.00	0.5132
Vehicle	Proximal dendrite spine density	12	12.49	17.63	23.37
	Distal dendrite spine density	12	14.31	19.06	28.11
Post-Pubertal GBX Administration
GBX	Proximal dendrite spine density	10	4.35	5.30	6.50	0.2165
	Distal dendrite spine density	8	4.15	7.06	8.70	0.0666
Vehicle	Proximal dendrite spine density	12	5.61	7.80	11.42
	Distal dendrite spine density	9	8.45	10.25	11.59

^*denotes THP vs GBX comparison; Boldface type indicates statistical significance.