Table 1.
Correlation analysis of CSF biomarkers with hippocampal size and clinical cognitive tests in AD subjects from second cohort.
Vs CSF NPTX2 | Vs CSF aβ42 | Vs CSF tau | Vs CSF p-Tau | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Pearson r | p value | n | Pearson r | p value | n | Pearson r | p value | n | Pearson r | p value | |
Average Hippocampal Occupancy | 25 | 0.483 | 0.015 | 25 | 0.189 | 0.367 | 24 | −0.083 | 0.701 | 24 | 0.360 | 0.084 |
Dementia Rating Scale | 30 | 0.467 | 0.009 | 28 | 0.225 | 0.249 | 27 | −0.137 | 0.497 | 27 | 0.296 | 0.134 |
Digit Symbol Substitution | 24 | 0.446 | 0.029 | 23 | 0.127 | 0.565 | 22 | 0.095 | 0.673 | 22 | 0.043 | 0.849 |
Boston Naming Test | 28 | 0.208 | 0.288 | 27 | 0.098 | 0.628 | 26 | −0.084 | 0.682 | 26 | 0.288 | 0.154 |
Phonemic Verbal Fluency Test | 28 | 0.200 | 0.308 | 27 | −0.079 | 0.694 | 26 | −0.207 | 0.310 | 26 | 0.133 | 0.519 |
Semantic Verbal Fluency Test | 28 | 0.385 | 0.043 | 27 | 0.396 | 0.041 | 26 | 0.121 | 0.557 | 26 | 0.036 | 0.863 |
Wisconsin Card Sorting Task_categories achieved | 22 | 0.445 | 0.038 | 21 | 0.046 | 0.842 | 20 | −0.179 | 0.453 | 20 | −0.057 | 0.812 |
Wisconsin Card Sorting Task_perseverative errors | 22 | −0.324 | 0.142 | 21 | 0.147 | 0.526 | 20 | 0.013 | 0.956 | 20 | −0.153 | 0.519 |
Visual Reproduction Test_immediate recall | 24 | 0.432 | 0.035 | 23 | 0.149 | 0.497 | 22 | 0.325 | 0.140 | 22 | 0.292 | 0.187 |
Visual Reproduction Test_delayed recall | 24 | 0.345 | 0.099 | 23 | 0.123 | 0.577 | 22 | −0.392 | 0.072 | 22 | −0.013 | 0.955 |
Block Design | 28 | 0.446 | 0.017 | 27 | 0.082 | 0.683 | 26 | −0.111 | 0.590 | 26 | 0.004 | 0.984 |
Clock Drawing_command | 28 | 0.337 | 0.079 | 27 | 0.040 | 0.845 | 26 | −0.119 | 0.563 | 26 | 0.087 | 0.673 |
Clock Drawing_copy |
28 | 0.011 | 0.955 | 27 | 0.106 | 0.600 | 26 | −0.246 | 0.225 | 26 | 0.161 | 0.434 |
California Verbal Learning Test_list B recall |
20 | 0.520 | 0.019 | 20 | 0.668 | 0.001 | 19 | 0.200 | 0.411 | 19 | −0.124 | 0.613 |
California Verbal Learning Test_recognition | 20 | 0.109 | 0.647 | 20 | −0.096 | 0.687 | 19 | 0.046 | 0.851 | 19 | 0.221 | 0.364 |
Significant correlations (p < 0.05) are highlighted in yellow.