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. 2017 Apr 25;6:e23043. doi: 10.7554/eLife.23043

Figure 2. Mutual insertion of loops into pockets of binding partners.

Figure 2.

(a) The MIR loop of nAChR α1 inserts into a surface pocket between the variable domains of the heavy and light chains (VH and VL) of Fab35 (orange) while the N-terminal helix sits into a groove on the surface of the heavy chain. (b) The CDR-H3 (H3) from the heavy chain of Fab35 inserts into a surface pocket between the MIR loop and the N-terminal helix on the nAChR α1 ECD.

DOI: http://dx.doi.org/10.7554/eLife.23043.007