Table 2. Top MDD-associated genes at 0.25 FDR.
| Gene Name | p-value | Direction | Function |
|---|---|---|---|
| MINOS1 | 5.00E-06 | − | Mitochondrial component |
| COPG | 8.00E-06 | + | Vesicle trafficking (Golgi-to-ER) |
| SYF2 | 2.93E-05 | − | Splicing factor |
| EHMT2 | 1.26E-04 | + | Histone methylation |
| UBAP2L | 1.26E-04 | + | Transcription activation/acetylation |
| MAFK | 1.26E-04 | − | Transcription activation/repressor |
| MX1 | 1.26E-04 | + | Immune function |
| C1ORF101 | 1.26E-04 | + | (not available) |
| SNRNP35 | 1.26E-04 | − | Splicing factor |
| FAM120AOS | 1.47E-04 | − | (not available) |
| NOP2 | 1.48E-04 | + | Cell cycle regulation |
| SRSF5 | 1.64E-04 | − | Splicing factor |
| TNFRSF10B | 2.52E-04 | + | Apoptosis, immune function |
| PIPOX | 2.52E-04 | + | (not available) |
| OAS1 | 2.52E-04 | + | Immune function |
| RABEPK | 2.52E-04 | + | Vesicle trafficking |
| SEMA3C | 2.52E-04 | + | Axon guidance |
| CINP | 2.52E-04 | − | Cell cycle regulation |
| H6PD | 3.78E-03 | − | ER, converting cortisone to cortisol |
| CCNI | 3.78E-03 | − | Cell cycle regulation |
| CROCC | 3.78E-03 | − | Cell cycle |
| IFIT3 | 3.78E-03 | + | Immune function |
| MRFAP1 | 3.78E-03 | − | Cell cycle regulation |
| STIP1 | 5.04E-04 | + | Axon guidance |
| MORC3 | 5.04E-04 | + | RNA binding |
| SDK1 | 5.04E-04 | − | Axon guidance |
| RGPD1 | 5.04E-04 | + | RNA binding |
| NXT1 | 5.04E-04 | + | RNA binding and transport |
| PACSIN1 | 5.04E-04 | + | Immune function, vesicle trafficking |
The table shows the top 29 genes (0.25 FDR) associated with MDD status. “Direction indicates whether the association was with increased (+) or decreased (-) expression.