Table 3. Enrichment p-values for association of IFN α/β signaling pathway and MDD.

Pathway	N=30	N=60	N=100	N=150	N=200	N=300	N=500
Interferon α/β signaling pathway	0.25 FDR	1.0E-06	7.0E-07	3.0E-11	2.0E-11	3.0E-13	3.0E-16

Using the hypergeometric test, over-representation of pathways among the top N associated genes was assessed for significance. The table shows results for the significantly over-represented pathway at 0.05 FDR (see Supplementary Table S7 for complete list of genes and single gene association p-values).