Table 4. IFN α/β signaling pathway genes with the strongest associations with MDD.
| Gene Name | p-value | Rank among all genes | Direction |
|---|---|---|---|
| MX1 | 1.26E-04 | 7 | + |
| OAS1 | 2.52E-04 | 15 | + |
| IFIT3 | 3.78E-04 | 22 | + |
| PTPN6 | 1.26E-03 | 43 | + |
| ADAR | 1.26E-03 | 45 | + |
| IRF7 | 1.64E-03 | 53 | + |
| IFIT1 | 3.15E-03 | 100 | + |
| USP18 | 3.78E-03 | 121 | + |
| ISG15 | 3.78E-03 | 122 | + |
| OAS2 | 4.16E-03 | 127 | + |
| IRF8 | 6.93E-03 | 185 | + |
| IFIT2 | 7.30E-03 | 201 | + |
| OAS3 | 7.56E-03 | 208 | + |
| MX2 | 8.44E-03 | 226 | + |
| IRF9 | 1.07E-02 | 274 | + |
| IFI6 | 1.13E-02 | 285 | + |
| OASL | 1.44E-02 | 352 | + |
| XAF1 | 1.49E-02 | 362 | + |
| IFI35 | 1.65E-02 | 404 | + |
| IFNAR2 | 4.99E-02 | 1030 | − |
The table shows the top twenty genes (those associated with nominal p-value < 0.05) in the interferon α/β signaling pathway, along with p-values, direction of effect, and association rank among all expressed genes.