Table 4.
Toxicologic Evaluation of 16aa
| parameter | units | control | 3 mg/kg 16a | 10 mg/kg 16a | 50 mg/kg 16a |
|---|---|---|---|---|---|
| white blood cells | 109/L | 3.55–9.83 | 3.73–7.99 | 4.95–7.03 | 3.65–7.1 |
| lymphocytes | 109/L | 3.44–8.88 | 3.61–6.78 | 3.94–5.84 | 3.5–5.62 |
| monocytes | 109/L | 0.04–0.36 | 0.11–0.34 | 0.08–0.28 | 0.04–0.35 |
| granulocytes | 109/L | 0.06–0.36 | 0.01–0.91 | 0.61–0.93 | 0.08–1.13 |
| red blood cells | 1012/L | 10.37–11.76 | 10.37–11.33 | 9.22–10.93 | 8.99–10.98 |
| hemoglobin | g/dL | 13.2–14 | 12.8–14 | 11.7–14.1 | 12.2–13.5 |
| albumin | g/dL | 3.2–3.4 | 3.3–3.4 | 2.9–3.4 | 2.6–3.1 |
| alkaline phosphatase | U/L | 87–134 | 85–127 | 85–113 | 80–86 |
| alanine aminotransferase | U/L | 47–87 | 40–134 | 44–46 | 37–52 |
| amylase | U/L | 926–981 | 878–1206 | 816–1054 | 760–967 |
| blood urea nitrogen | mg/dL | 15–19 | 17–19 | 11–16 | 14–22 |
| phosphate | mg/dL | 5.7–9.5 | 5.1–5.6 | 5.7–6.2 | 5.5–8.1 |
| creatinine | mMg/dL | 0.2–0.3 | 0.2–0.4 | 0.2–0.3 | 0.2–0.3 |
| Na+ | mmol/L | 150–155 | 150–155 | 144–151 | 145–153 |
| K+ | mmol/L | 7.7–7.9 | 7.3–7.5 | 7.2–8.2 | 6.3–6.7 |
| glucose | mg/dL | 70–94 | 80–90 | 87–129 | 136–163 |
a
The indicated doses of compound 16a were administered by intraperitoneal injection daily for 7 days and blood was collected after an additional 7 days of observation. The ranges of values for cell counts and blood chemistry are given.