Table 1.

Model parameters

Parameter	Description	Value	Units	Reference
α rbc	O2 solubility in RBCs	3.38 ×10−5	cm3O2 mmHg−1 cm−3	[8]
α p	O2 solubility in plasma	2.82 ×10−5	cm3O2 mmHg−1 cm−3	[8]
α w	O2 solubility in endothelium	3.89 ×10−5	cm3O2 mmHg−1 cm−3	[8]
α t	O2 solubility in tissue	3.89 ×10−5	cm3O2 mmHg−1 cm−3	[8]
Drbc	O2 diffusivity in RBCs	9.5 ×10−6	cm2/s	[8]
Dp	O2 diffusivity in plasma	2.18 ×10−5	cm2/s	[8]
Dw	O2 diffusivity in endothelium	8.73 ×10−6	cm2/s	[8]
Dt	O2 diffusivity in tissue	2.41 ×10−5	cm2/s	[8]
DHb	Hemoglobin diffusivity in RBCs	1.44 ×10−7	cm2/s	[8]
k_	Dissociation rate constant	44	s−1	[8]
Lrbc	RBC length	8.35	μm	Calculated
n	Hill exponent	2.64	--	Fitted from [40]
NHb	Molar density of heme groups	2.03 ×10−5	mol/cm3	[8]
P 50	Po2 at hemoglobin half-saturation	47.9	mmHg	Fitted from [40]
Pcrit	Critical Po2 in tissue	1.0	mmHg	[12]
Prbc,a	RBC Po2 at capillary entrance	90	mmHg	Based on [25]
rc	RBC radius	1.5	μm	[29]
rp	Plasma radius	2.0	μm	[35]
rw – rp	Capillary wall thickness	0.6	μm	[2]
V mol,O2	Molar volume of oxygen	2.54 ×104	cm3O2/mol	Ideal gas law at 36.9°C
Vrbc	RBC vol ume	59	μm3	[32]