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Oxytocin-induced reduction in binge-like ethanol consumption is blocked by pretreatment with an oxytocin receptor antagonist. Oxytocin (1 mg/kg) reduced ethanol intake in the DID model and this effect was reversed by pretreatment with the oxytocin receptor antagonist L368,889 (10 mg/kg). Values are mean ± s.e.m. (N= 10/group). Significantly differs from the vehicle-saline condition: *** (p< 0.001). Significantly differs from the L368,889-OXT group: ++ (p< 0.01).
