Table 2.
Correlates of Frailty Status Among Kidney Transplant (KT) Recipients (n=663). The frailty score is calculated using the cutpoints from the Fried Frailty Phenotype (1). Frailty is defined as a score of 3 or more and intermediate frailty as a score of 2.
| Correlate | Intermediately frail | Frail | ||
|---|---|---|---|---|
|
| ||||
| PR (95% CI) | P value | PR (95% CI) | P value | |
| Age ≥ 65 years | 1.82 (1.11, 2.96) | 0.02 | 2.22 (1.21, 4.07) | 0.01 |
| Female sex | 1.17 (0.79, 1.73) | 0.43 | 0.92 (0.56, 1.53) | 0.76 |
| Black race | 0.68 (0.44, 1.06) | 0.09 | 0.97 (0.55, 1.69) | 0.90 |
| Obesity | ||||
| Normal weight (BMI<25) | Ref | Ref | ||
| Overweight (BMI 25-29) | 0.85 (0.54, 1.36) | 0.51 | 1.11 (0.62, 1.96) | 0.73 |
| Obesity (BMI ≥30) | 1.12 (0.69, 1.81) | 0.65 | 1.11 (0.61, 2.01) | 0.74 |
| IADL disability | 1.41 (0.74, 2.67) | 0.29 | 3.22 (1.72, 6.06) | <0.001 |
| CESD depression | 3.52 (1.34, 9.26) | 0.01 | 11.31 (4.02, 31.82) | <0.001 |
| < High school education | 1.68 (0.75, 3.75) | 0.21 | 3.10 (1.30, 7.36) | 0.01 |
| Current smoker | 0.71 (0.31, 1.64) | 0.42 | 0.45 (0.12, 1.62) | 0.22 |
| No residual kidney function | 0.76 (0.47, 1.21) | 0.25 | 1.56 (0.69, 3.52) | 0.27 |
| Time and type of dialysis | ||||
| Not on dialysis | Ref | Ref | ||
| Hemodialysis; 0-2 y | 2.35 (1.17, 4.69) | 0.02 | 1.43 (0.51, 4.06) | 0.49 |
| Hemodialysis; >2 y | 1.19 (0.63, 2.25) | 0.58 | 1.08 (0.38, 3.07) | 0.89 |
| Peritoneal dialysis; 0-2 y | 1.08 (0.46, 2.54) | 0.86 | 0.67 (0.20, 2.25) | 0.51 |
| Peritoneal dialysis; >2 y | 1.37 (0.49, 3.83) | 0.54 | 1.25 (0.38, 4.09) | 0.70 |
| Charlson Comorbidity Index | ||||
| 0 points | Ref | Ref | ||
| 1-2 points | 0.82 (0.48, 1.41) | 0.48 | 1.31 (0.66, 2.58) | 0.43 |
| ≥3 points | 1.58 (0.62, 3.99) | 0.33 | 0.61 (0.12, 3.12) | 0.55 |
| Cause of ESRD | ||||
| Hypertension | Ref | Ref | ||
| Diabetes | 1.11 (0.64, 1.92) | 0.71 | 1.06 (0.53, 2.12) | 0.86 |
| Glomerulonephritis | 0.47 (0.14, 1.58) | 0.22 | 1.27 (0.39, 4.10) | 0.69 |
| Other | 0.98 (0.62, 1.57) | 0.95 | 0.88 (0.49, 9.31) | 0.67 |
| Self-rated HRQOL | ||||
| Excellent/Very good | Ref | Ref | ||
| Good | 1.37 (0.83,2.25) | 0.22 | 2.80 (2.29, 6.07) | 0.01 |
| Fair/Poor | 1.80 (1.07, 3.05) | 0.03 | 3.71 (1.48, 9.31) | 0.01 |
| Donor type | ||||
| Live | Ref | Ref | ||
| Deceased | 1.51 (0.98, 2.32) | 0.06 | 1.16 (0.67, 2.00) | 0.59 |
ADL disability was excluded from the model for KT recipients because there were no participants with an ADL disability and intermediate frailty.