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. 2016 Oct;109:69–77. doi: 10.1016/j.neuropharm.2016.05.013

Fig. 3.

Fig. 3

Effects of bilateral SNc lesion on task acquisition, operant responding and motivation: A. Over the 7 sessions, no difference was observed between sham and lesioned rats (all impulsivity traits included; 2-way RM-ANOVA) B. No difference in the total number of rewards obtained was seen between subpopulations of both groups for the last FR1 session (2-way ANOVA). C. The number of responses required to obtain a pellet increased according to the following progression (1, 3, 4, 6, 8, 11, 13, 16, 19, 23, 27, 32, 38, 44, 50, 58, 67, 77, 88, 100). No difference in breakpoint (the maximum number of wheel turn) was reported between both groups (along the 3 PR sessions (all impulsivity traits included; 2-way RM-ANOVA). D. No difference in breakpoints was seen between subpopulations of both sham and lesioned groups for the last PR session (2-way ANOVA). Sham: LI: n = 5, Int: n = 12, HI: n = 4; Lesioned: LI: n = 6, Int: n = 11, HI: n = 6.