Fig. 3.

IFNγ ELISpot responses post-vaccination for intramuscular and intradermal routes. (A) Shows responses to 85A summed pooled peptides calculated by summing across all peptide pools A–G at each time-point. This could potentially result in duplicate counting of cells that responded to any of the 10mer overlap regions, since these could occur in two pools with adjacent peptides, but allows direct comparison with immunogenicity data from previous trials with MVA85A. (B) Shows responses to the 85A single pool and (C) to PPD. Box and whisker plots show median, interquartile range, and minimum and maximum values. In the 85A single pool and PPD graphs, a value of 1667 SFC/1 × 10⁶ PBMC represents a blackout in the ELISpot well.