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Components of the mTORC1 and mTORC2 signaling complexes. Both the mTORC1 and mTORC2 complexes contain mTOR, MLST8, and DEPTOR. However, their major differences lie in the co-binding of Raptor to the mTORC1 complex and Rictor to the mTORC2 complex, in addition to their other binding partners including PRAS40 and PROTOR1/2 and SIN1 respectively (Laplante and Sabatini, 2012).
