Fig. 6.

AAV-CatB-mediated transduction improves learning and memory in APP/PS1 mice. a Non-Tg (n = 10), AD (n = 9), AAV-GFP (n = 8) or CatB (n = 10)-injected APP/PS1 mice were tested by the RAWM task at 6–7 months of age. Non-Tg serves as a positive control for the spatial learning task. The compiled average errors for day 1–3, 4–6 and 7–9 are shown. Bars represent mean ± S.E.M. *p < 0.05, two-way ANOVA, Bonferroni post hoc test. b Immunohistochemical detection of c-fos-labeled cells in the dentate GCL. Scale bar, 200 μm. c Quantification of the number of c-fos-labeled cells (n = 7 mice per group, 12 sections per mouse). Bars represent mean ± SEM. ^a,b,c p < 0.05, ^aaa p < 0.001, ^a,aaa vs non-Tg, ^b vs uninjected APP/PS1, ^c vs AAV-GFP-injected APP/PS1, one-way ANOVA, Newman-Keuls post hoc test