Figure 5.

Daily moderate exercise (DME) of NZM2410/J mice suppresses expression of proinflammatory mediators. Beginning at 11–13 weeks of age, mice were exposed to DME consisting of treadmill walking (8.5 m/min, 45 min/day) for comparative analysis with non-exercised control mice. Serum was collected bi-weekly for longitudinal analysis and weights were recorded weekly (n = 9 per experimental condition). ELISA measurements from serum were used to determine average cytokine scores from samples collected at experimental endpoint (BUN > 50 mg/dL; weight loss > 20%) and the 3 previous time points for each mouse. Values are the mean ± SEM. Significant differences derived from a nonparametric Mann-Whitney U-test. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001 vs. non-exercised controls.