Figure 3.

The Ctx-TRN pathway contributes to controlling absence seizures. (A) State analysis of ϕ_e as a function of the coupling strength of the Ctx-TRN pathway v_re. Enhancing the coupling strength v_re could push the firing pattern from the SWD oscillation (II) to the simple oscillation (III) and to the low firing (IV). (B) The dominant frequency of the cortical oscillations ϕ_e changes with the enhancement of v_re. (C) The mean firing rates (MFRs) of three neural populations that the Ctx (“^*”), the SRN (“ ◦ ”), and TRN (“ □ ”) as a function of v_re. The gray regions in (A–C) describe the regions of the typical 2–4 Hz SWDs, and the dashed green lines are used to show the demarcations of different dynamical states in the control process of absence seizures. (D) Changes of mean potential as a function of v_re. V_Ctx-TRN denotes the mean potential from the Ctx to TRN, V_SRN-TRN represents the mean potential from the SRN to TRN, V_TRN shows the mean potential of TRN.